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KMID : 0370220150590060251
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Yakhak Hoeji
2015 Volume.59 No. 6 p.251 ~ p.258
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Anti-inflammatory Effects of Staphylea bumalda Leaves Extracts in Murine Macrophages
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김정화:Kim Jeong-Hwa
이재권:Lee Jae-Kwon
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Abstract
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Aim of the present study was to investigate whether methanol extract from the leaves of Staphylea bumalda could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines, Raw 264.7 cells. The extract reduced nitric oxide (NO), cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines production from LPS-stimulated Raw 264.7 cells. These inhibitory effects were associated with decreases in the phosphorylation of MAP kinases and the activity of NFκB signal pathways. Our results indicate that Staphylea bumalda significantly inhibits the inflammatory activity of activated macrophages, suggesting that Staphylea bumalda could be a potential candidate for the
treatment of inflammatory disease.
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KEYWORD
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Staphylea bumalda, nitric oxide, cytokine, anti-inflammation, macrophages
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